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Depression? High Cholesterol? Stubborn Weight Gain?–Maybe it is Thyroid

By Dr. Paul Varnas | August 1, 2008

You’ve seen this patient; she (usually a she) is tubby, tired and depressed. Her hair is brittle, skin is dry and she can’t seem to lose weight no matter what she does. You look up hypothyroidism in the medical dictionary and her picture appears next to the two paragraph description of the condition. She cries for no reason, catches a lot of colds, her ankles swell and she is puffy under the eyes. You notice that the lateral third of her eyebrows is missing. She may or may not be taking antidepressants or statins. You suggest that her thyroid may the source of her problems and she says, “But the doctor said my thyroid was fine”.
More than likely the doctor checked TSH and found it within normal limits. You may take this opportunity to tell her that TSH isn’t even a thyroid hormone—it’s a pituitary hormone. More importantly, using it as your only criterium isn’t a very good way to diagnose thyroid problems.
There are flaws in how we diagnose hypothyroidism. The British Medical Journal [BMJ 2000;320:1332-1334 (13 May)] published an article examining this. The authors concluded that there are some problems with how hypothyroidism is diagnosed. The article points out that when diagnosing the thyroid, there is not adequate research showing us the relative importance of lab tests and symptoms. TSH production is affected by the level of thyroid hormone, but it is also affected by other things. Also, there is a need to consider the possibilities of false positive and false negative results when looking at lab tests related to the thyroid. Furthermore, we don’t fully understand how various illnesses affect TSH and the thyroid hormones.
Dr. Broda Barnes was critical of the lab work available to diagnose hypothyroidism. Dr. Barnes felt that the basal body temperature should be between 97.8 and 98.2 degrees, and used temperature to diagnose hypothyroidsm. If a patient has a low basal body temperature and hypothyroid symptoms, that is justification to treat the thyroid. The problem is that many things can cause a low temperature. Using basal body temperature and symptoms to make this diagnosis is also unsatisfactory.
It is important to understand how to diagnose hypothyroidism—so many health problems are linked to it. Many people on antidepressants should be getting thyroid support. Research appearing in the American Journal of Psychiatry (March 1993;150:3:508-510) suggests that the thyroid may be involved with some cases of depression. It was a small study that looked at 16 patients with subclinical hypothyroidism and 15 with normal thyroid function. The frequency of depression over the course of a lifetime was higher in the group with subclinical hypothyroidism.
Hypothyroidism can cause high cholesterol and heart disease. Now, research appearing in the Annals of Internal Medicine (2000; 132(4):270-8) shows that subclinical hypothyroidism and thyroid autoimmunity can also increase the risk of heart disease. Could it be that your patient who is on cholesterol lowering medication should actually be getting thyroid support? Hypothyroidism can be responsible for miscarriages. If an expectant mother has hypothyroidism and doesn’t miscarry, her baby will have a lower IQ than if her thyroid was normal [According to a study published in the New England Journal of Medicine (1999;341:549-555, 601-602),]. Problems losing weight, dry skin and immune system problems may have the thyroid at their root.
Fortunately, a number of doctors have been wrestling with this problem and there are now ways to combine lab information with symptoms and come up with a diagnosis—and a safe and reasonable treatment. When you treat with nutrition, you are using a therapy that has great potential to get good results without causing the same kind of risk to the patient that drug therapy poses. In the next installment I will place some guidelines and recommend some resources.
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Topics: General | 3 Comments »

3 Responses to “Depression? High Cholesterol? Stubborn Weight Gain?–Maybe it is Thyroid”

  1. D Brown Says:
    September 23rd, 2009 at 11:05 am

    I have recently noticed this; when my tsh is down my cholesterol goes up and vice versa. I do have some symptoms that are bad if the tsh is kept high, but my cholesterol is within normal limits, so i feel as if i have a choice….. either feel good and possibly die of a heart attack or put up with symptoms that keep me from working so i can live longer. btw…I am on Effexor for depression, thanks to this article I now know why I cry for no reason, out of the blue.

  2. Dr. Paul Varnas Says:
    September 23rd, 2009 at 1:57 pm

    That is unusual, usually cholesterol goes up with hypothyroidism.

  3. Dr. Paul Varnas Says:
    September 24th, 2009 at 4:57 pm

    That is unusual, usually when thyroid function improves, cholesterol goes down